Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding protein-protein interactions of the fused protein.Kim HJ, Lee JH, Lee KB, Shin JW, Kwon MA, Lee S, Jeong EM, Cho SY, Kim IG.Exp Mol Med. 2021 Jan;53(1):115-124. doi: 10.1038/s12276-020-00549-9. Epub 2021 Jan 13.PMID: 33441971 https://pubmed.ncbi.nlm.nih.gov/33441971/